The diagnosis and treatment of cholangiocarcinoma
Xinjiang Medical University, The first affiliated hospital of Xinjiang Medical University.
Research Article
World Journal of Advanced Research and Reviews, 2024, 24(02), 1847–1854
Article DOI: 10.30574/wjarr.2024.24.2.3530
Publication history:
Received on 09 October 2024; revised on 15 November 2024; accepted on 18 November 2024
Abstract:
Background: Cholangiocarcinoma (CCA) is the second most common primary hepatic tumor. In recent years, its prognosis has improved because of wide resections and the establishment of local treatment and chemotherapy.
Objective: To determine the diagnosis and treatment of cholangiocarcinoma
Methods: A cross-sectional study was conducted at First affiliated hospital of Xinjiang Medical University, Urumqi, Xinjiang, China which was performed between December 2023 to July 2024, The total number of patients in our study were 100. The number of Male patients in our study were 55 and female were 45. For all patients, we did diagnostic tests, (CA-19-9), (MRCP, CT Scan). We also took stages of cholangiocarcinoma. For treatment, we used surgery, RFA procedure and chemotherapy. We took parameters of BMI (kg/m2) for all patients. We excluded pregnant women and children in our study. Data was tabulated and analyzed by SPSS version 27.
Results: In a current study total 100 patients were enrolled. The minimum age of patients were 53 years and the maximum age of the patients were 78 years. The mean age were 65.10±7.752 years. The minimum BMI of patients were 23 (kg/m2) and the maximum BMI 39 (kg/m2). The minimum ALT were 73 and the maximum were 105 (u/l). The minimum AST were 60 and the maximum were 96 (u/l). The minimum ALP were 140 and the maximum were 250 (u/l).The mean of ALP were 181.80±24.96 (u/l).The frequency of Jaundice were not present in 30 patients and were present in 70 patients. The frequency of Itchy skin were not present in 65 patients and were present in 35 patients. The frequency of dark urine were not present in 80 patients and were present in 20 patients.
In Figure 3, we can see the treatment of cholangiocarcinoma, (Biliary drainage 10%, Chemotherapy 15%, RFA 35%, and Surgery in 40% of patients).The frequency of CA-19-9 were negative in 25 patients and were positive in 75 patients. P-Value were 0.03. The frequency of diagnose of cholangiocarcinoma on CT scan were 30 and diagnose on MRCP were 70 and its percentage were 70%.In our study P-Value were less than (< 0.05).
Conclusion: We concluded that Cholangiocarcinoma best and early diagnosis on MRCP. Surgery and RFA are the two good methods for the treatment of cholangiocarcinoma. Stage 2 is the most common stage of cholangiocarcinoma in our study.
Keywords:
Magnetic resonance cholangiopancreatography (MRCP); Percutaneous transhepatic cholangiography (PTC); Endoscopic retrograde cholangiography (ERC); Computed tomography (CT scan); Magnetic resonance imaging (MRI)
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